To those of you that have implemented Nearstore and A-SIS on your primary storage:
 
1.  Have you seen any difference in overall filer performance?
2.  If you have LUNs, how are your space savings on those volumes?
 
I know that enabling Nearstore does some system tweaking in the background to increase the number of concurrent backup streams that can be running, but I don't know what else it tweaks that may adversely affect performance of a primary storage system.  Afterall, it was originally designed to run as a secondary storage platform.